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 Medical Encyclopedia
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Insulin
therapy Conventional vs. Intensive Insulin Therapy Insulin Delivery Devices
Insulin information History of Insulin Types
of Insulin Reactions to Insulin What is insulin? What is insulin used for? Cautions Side Effects of Insulin Interactions How is insulin manufactured? Contents of Insulin
Action of Commonly Prescribed Insulin (chart)
The right insulin therapy can reduce the risk of long-term complications
Description of Types of Injected Insulin
Available -- Animal insulin -- Chemically modified
insulins -- Non-hexameric insulins -- Aspart insulin
-- Lispro insulin -- Shifted isoelectric point insulin -- Glargine insulin -- Detemir insulin
-- Inhaled Insulin
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Insulin
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Insulin (pronounced in-suh-lin)
Definition: Insulin is a polypeptide hormone produced in the beta islet cells and secreted by the islets of Langerhans of the pancreas. It is just one of the hormones that helps the body convert and use energy from food (especially from carbohydrates and fat) into glucose. Insulin also helps the body by acting as a "fat storing" hormone.
Insulin acts like a "key" to open cells so that they can receive nourishment in the form of blood sugar (glucose). Without insulin the cells will not open and they will starve. Blood sugar can rise to dangerous levels and serious, even fatal complications of diabetes will result. Without insulin (either naturally occurring or from injection) a person will soon die.
There are many types of insulin and they each serve a different purpose in treating diabetes mellitus.
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Type of Insulin
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Examples (May not all be available in the U.S.)
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Rapid-acting insulin begins to work very quickly -- about 5 minutes after injecting or infusing it. It peaks at about 1 hour and then continues to work for about 4 hours in the body.
Rapid-acting insulin is generally used to cover food eaten when taking shots (which is why it may be called "mealtime insulin"), but almost always it is the only insulin used in an insulin pump.
Rapid insulin may be used in an insulin pump to cover meal and correction boluses as well as is used for administering basal insulin.
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Apidra - insulin glulisine (rDNA origin injection
Humalog (Humalog Pen, Lispro-PFC, insulin-lispro)
NovoLog - NovoRapid, aspart (rDNA origin)
Rapid insulins are clear in color.
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Regular or short-acting insulin usually enters the bloodstream
within 30-45 minutes after injection or infusion and peak about 2-3 hours later. Short-acting insulin continues to work in the body for 3 to 6 hours and sometimes a little longer.
This type of insulin may also be used for mealtime boluses.
Regular insulin is also referred to as "Toronto" insulin in certain parts of Canada.
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Humulin-R, Humulin R U-500
Novolin
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Intermediate-acting insulin enters the bloodstream about 2 to 4
hours after it is injected and peaks 4-10 hours later. It is effective for about 12 to 16 hours.
These insulins are often referred to as "NPH."
Intermediate-acting insulin is insulin mixed with something that
makes the body absorb the insulin more slowly. While an allergy to insulin itself is rare, some people may be allergic to the buffering agents mixed in with intermediate-acting insulin.
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Humulin-N - Humulin-N Pen - (NPH human insulin (rDNA ORIGIN) isophane
suspension 100 UNITS per ML (U-100))
Novolin-N - Generic Name: insulin isophane. Brand
Names: Humulin N, Humulin N Pen, Iletin II NPH Pork, Insulin Purified NPH
Pork, Novolin N, Novolin N Innolet, Novolin N PenFill
Intermediate insulins are cloudy in color.
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Long-acting insulin enters the bloodstream 2-4 hours after
injection and is generally effective for 20 to 24 hours.
Long-acting insulin is effective for covering basal insulin for those who are in daily injections of insulin. It should never be used in an insulin pump and cannot be mixed in a syringe with other insulin.
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Lantus® (insulin glargine [rDNA origin] injection). Because of the dependable, long-acting nature of Lantus, it is sometimes referred to (slang) as the "poor man's pump."
Levemir - insulin detemir (rDNA origin)
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Other Types of Insulin
Inhaled Insulin
Oral Insulin - Currently, there is no such product on the market to supply oral insulin.
Pre-mixed insulin - Insulin may also come premixed, that is a combination of rapid or fast-acting insulin and intermediate-acting insulin.
Different mix rations include: 10/90, 20/80. 30/70 (the most commonly prescribed mix), 40/60, 50/50, and Mix 25.
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Inhaled insulin
Exubera - human [rDNA origin]) Inhalation Powder
Exubera Inhaler. It is made of blisters of recumbent human insulin that is administered through a large inhaler device.
Pre-Mixed Insulin
Humulin 70/30 and Humulin 50/50, also Humulin 10/90
Novolin 70/30
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All persons with the juvenile form of type 1 diabetes need to take insulin to live.
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Want help determining how to calculate your need for insulin? First, be sure to check with your doctor but you can also use Insulin Pumper's insulin calculating tool to better understand how your doctor might determine your need for insulin.
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