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Islets of Hope |
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He makes an excellent point that those of us who are non- diabetics should remember -- there's still no cure.
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Islets of Information Links Lowering Resistance To Insulin May Delay Or Prevent Onset Of Type 2 Diabetes (June 12, 2005) — Type 2 diabetes may be significantly delayed or prevented through medication that takes the load off of the body's delicate insulin-producing cells. UT Southwestern Researchers Uncover Gene Variant That Appears To Predict Type 2 Diabetes (March 29, 2005) — A particular gene variant that could serve as a predictor for type 2 diabetes has been identified by researchers at UT Southwestern Medical Center. Diabetes And Depression Can Be A Fatal Mix (October 27, 2005) — In a University of Washington and Group Health Cooperative three-year study, people whose type 2 diabetes was accompanied by minor or major depression had higher mortality rates than did patients with type 2 diabetes alone. Type 2 Diabetes Is Increasing Among Children All Over The World (May 11, 2005) — A review article in the May issue of The Journal of Pediatrics reports that the rate of type 2 diabetes among children worldwide appears to have increased significantly over the last 15 years. High Blood Sugar Levels A Risk Factor For Heart Disease (September 14, 2005) — An elevated blood glucose level is the defining feature of diabetes, but until now it was unclear whether elevated glucose levels contributed independently to increasing heart-disease risk. Lowering blood sugar levels could reduce the risk of coronary heart disease in both diabetics and non-diabetics, according to researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions. > full story Long-Term Coffee Consumption Significantly Reduces Type 2 Diabetes Risk (January 6, 2004) — A study by researchers at the Harvard School of Public Health and Brigham and Women?s Hospital has found that participants who regularly drank coffee significantly reduced the risk of onset of type 2 diabetes, compared to non-coffee drinking participants. > full story Elevated Glucose Levels And Diabetes Are Associated With Increased Risk For Cancer (January 19, 2005) — New research involving more than one million people indicates that having high fasting serum glucose levels and diabetes are risk factors for several major cancers, according to a study in the January 12 issue of JAMA. Canadian Study Demonstrates New Approach To Achieving Diabetes Control (June 16, 2005) — Results of an all-Canadian study announced June 13 at an international diabetes congress demonstrate that patients with type 2 diabetes can safely achieve target blood sugar (glycemic) levels faster and more frequently when insulin is used earlier. High Blood Sugar Levels A Risk Factor For Heart Disease (September 14, 2005) — An elevated blood glucose level is the defining feature of diabetes, but until now it was unclear whether elevated glucose levels contributed independently to increasing heart-disease risk. Lowering blood sugar levels could reduce the risk of coronary heart disease in both diabetics and non-diabetics, according to researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions. Saturated Fats Combined With Genetic Trait Implicated In Development Of Type 2 Diabetes (June 29, 2005) — A University of Alberta team of researchers has discovered an additional 2 million Canadians who have a high fat diet or are overweight may be at increased risk for developing type 2 diabetes if they carry a particular type of common specific genetic trait known as a polymorphism. > full story Drugs Aid Weight Loss Among Type 2 Diabetes Patients (March 10, 2005) — A little-known drug called naltrexone provides a ?meaningful benefit? in helping alcoholics moderate their drinking, according to the latest review of evidence from 29 studies on four continents. > full story New Study Shows Targeted Lifestyle Changes Could Turn The Tide Aganst Diabetes And Heart Disease; Results Show A 20% Improvement In The Body's Ability To Use Insulin (October 3, 2001) — World-first research at the University of Otago in New Zealand could help reverse the world-wide epidemic of diabetes and significantly reduce heart disease. The study of 79 people aged 35-60 suggests a combination of intensive exercise and specific changes to diet could prevent or dramatically reduce the risk of adult-onset diabetes (type 2 diabetes) and heart disease. Type 2 Diabetes: Problems In The Furnace (August 24, 2005) — A detectable decline in energy production by mitochondria -- the organelles that are the cell's furnace for energy production -- seems to be a key problem leading to insulin resistance, and thus to type 2 diabetes, according to studies by Howard Hughes Medical Institute researchers. The researchers said that insulin resistance -- an impaired response to the presence of insulin -- is detectable as early as 20 years before the symptoms of diabetes become evident. Strong Statistical Correlation Between Prevalence Of Diabetes, Air Pollution (July 31, 2002) — A dramatic statistical correlation between the prevalence of diabetes and air pollution levels has been demonstrated by a University at Buffalo researcher who publishes his observations in the August issue of the journal, Diabetes Care. People With Diabetes More Sensitive To Cardiovascular Effects From Air Pollution (June 1, 2005) — People with diabetes may be at higher risk for cardiovascular problems when air pollution levels are higher, according to a new study of Boston-area residents. The ability of the blood vessels to control blood flow was impaired in adults with diabetes on days with elevated levels of particles from traffic and coal-burning power plants. Researchers Discover How A High-fat Diet Causes Type 2 Diabetes (December 29, 2005) — Howard Hughes Medical Institute researchers have discovered a molecular link between a high-fat, Western-style diet, and the onset of type 2 diabetes. In studies in mice, the scientists showed that a high-fat diet disrupts insulin production, resulting in the classic signs of type 2 diabetes. > full story Stanford Study Shows Drug For Treating Type-2 Diabetes May Limit Heart Disease Risk (June 18, 2003) — A drug used to treat high blood sugar in people with type-2 diabetes also may lower the risk of cardiovascular disease, according to research at Stanford University Medical Center. If larger studies confirm these results, the drug, called rosiglitazone, may be a good choice for patients with type 2-diabetes who require additional medications to prevent heart attacks. Insulin-sensitizing Drug Cut Diabetes Risk (April 12, 2005) — Researchers report that troglitazone lowered diabetes onset by 75 percent compared to placebo during the time participants were taking the drug, an average period of nearly 11 months. UVa Researchers Show That A Natural Carbohydrate Can Help Lower Blood Sugar (October 27, 2005) — A carbohydrate isolated from the liver lowers blood sugar levels after it is injected into diabetic rats, according to research carried out by a team of experts at the University of Virginia Health System. Curry Coloring And Fat Mix Could Help Diabetics (April 14, 2006) — Brisbane immunologist Dr Brendan O'Sullivan hopes to put a dent in skyrocketing rates of diabetes in Australia by creating a new treatment for type 2 diabetes. Brain Plays Key Role In Diabetes Therapy (January 11, 2006) — The brain plays a major role in the ability of insulin therapy to lower blood sugar in animals with diabetes, according to a new study in the January 11, 2006, Cell Metabolism. Strict Blood Sugar Control Cuts Diabetes Heart Risk : WEDNESDAY, Dec. 21 (HealthDay News) -- A 20-year study of people with type 1 diabetes shows that tight control of blood sugar levels cuts their risk of heart disease by more than half. Diabetes May Raise Risk of Pancreatic Cancer: Middle-aged, newly diagnosed patients more likely to develop disease. Reuters, August 11, 2005 Waist Size Linked to Insulin Resistance in Children: Can Waist Circumference Identify Children with the Metabolic Syndrome? Arch Pediatric Adolescene Medicine. 2005; 159:740-7444 Sleep Patterns May Lead to Risk of Diabetes: A study published in the April 25 issue of the Archives of Internal
Medicine has concluded that sleeping for less than six hours or for more
than nine hours a night was associated with a higher risk of risk of developing
diabetes and impaired glucose tolerance (IGT). Archives of Internal Medicine, 2005;165:863-867 Dark Chocolate is Good For You! New research shows that eating dark chocolate reduces the risk of damaging changes in the body that can lead to diabetes. But it works only if you eat plain, dark chocolate high in disease-fighting chemicals called flavanols. Milk or white chocolate is unlikely to have the same effect. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am. J. Clinical Nutrition, Mar 2005; 81: 611 - 614. [Story at Daily Mail: Abstract at Am. J. Clinical Nutrition; full text at Am. J. Clinical Nutrition, requires subscription.]
Promising Research Into Treatment of Nerve Damage Caused by Diabetes: Scientists at the University of Manchester, UK have announced the results of pre-clinical studies on a new treatment for nerve damage caused by diabetes that could lead to a reduction in the number of leg and foot amputations performed on people with diabetes. Excerpt posted on IDF, Press Release, July 26, 2005. Pioglitazone prevents reactive hypoglycemia in impaired glucose tolerance: (entire abstract that was available without subscritpion). A 42-year-old woman with hypoglycemic symptoms that occurred several hours after a meal visited our hospital. The hypoglycemic symptoms appeared when she was 37 years old, and her plasma glucose level had been assessed as less than 60 mg/dL when she experienced the symptoms. One year before, she had been diagnosed with reactive hypoglycemia by 75 g-oral glucose tolerance test (OGTT), which showed a normal glucose tolerance (NGT) pattern, and had begun taking an alpha-glucosidase inhibitor and nutritional treatment. A 75 g-OGTT on admission showed hypoglycemia at 240 min after glucose loading, excessive insulin secretion and an impaired glucose tolerance (IGT) pattern. A euglycemic–hyperinsulinemic clamp study demonstrated decreased insulin sensitivity. Therefore, we suspected that she had reactive hypoglycemia associated with insulin resistance and treated her with 15 mg/day pioglitazone. Her hypoglycemic symptoms completely disappeared after treatment with pioglitazone; insulin sensitivity in a euglycemic–hyperinsulinemic clamp study improved. Another 75 g-OGTT revealed that the excessive insulin secretion and hypoglycemia at 240 min after glucose loading had disappeared, and glucose tolerance was normalized from an IGT pattern to an NGT pattern. Thus, we believe that pioglitazone is effective for reactive hypoglycemia and aggravated glycemic metabolism associated with insulin resistance. Diabetes Research and Clinical Practice; Volume 69, Issue 3, Pages 209-312 (September 2005); page item #16. Effects of Goshajinkigan on insulin resistance in patients with type 2 diabetes: We investigated the effects of Goshajinkigan (GJG), a Chinese herbal medicine, on insulin sensitivity in patients with type 2 diabetes using the homeostasis model assessment of insulin resistance (HOMA-R) and the euglycemic insulin clamp procedure. Daily oral administration of GJG (7.5 g/day) was performed for 1 month in 71 type 2 diabetes patients: the GJG treatment group. HOMA-Rs were calculated before and after 1 month of GJG treatment and compared with those of 44 controls who were matched in terms of sex, age, body mass index (BMI) and HbA1c levels with the experimental group. In 64 patients out of the GJG treatment group, HOMA-R was calculated 1 month after discontinuation of treatment. In addition, euglycemic clamp was conducted in eight patients before and after the GJG treatment. HOMA-R was 4.78 ± 0.37 (means ± S.E.) before GJG treatment and significantly decreased to 4.02 ± 0.25 after GJG treatment (P = 0.019). No significant change was observed in the control group. HOMA-R returned to the pre-treatment level (P = 0.018) 1 month after GJG treatment discontinuation. Glucose infusion rates and metabolic clearance rates determined by the high-dose euglycemic clamp increased after 1 month of GJG treatment (from 9.6 ± 1.1 to 11.1 ± 0.7 mg/kg/min, P = 0.045 and from 7.9 ± 0.8 to 9.1 ± 0.8 ml/kg/min, P = 0.046, respectively). These results indicate that GJG administration might be useful for improving insulin resistance in patients with type 2 diabetes. Diabetes Research and Clinical Practice; Volume 69, Issue 3, Pages 209-312 (September 2005); page item #6.
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